Tag Archives: circularly permutated

Watching Neurons in action

Fluorescent sensors are important tools that can allow real-time, live, single molecule imaging of microscopic millisecond scale events. It is even better if these sensors are genetically encoded sensors (i.e. fluorescent proteins). We have already encountered the pH sensors pHluorin and pHTomato and the Ca2+ sensor GCaMP. There have been a few others, such as HyPer that detects H2O2 or ArcLight and ElectrikPk which are voltage sensors.

Now, the group of Loren Looger from HHMI Janelia  developed a sensor for a very important molecule: L-glutamate. Continue reading

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