One of the greatest breakthroughs of the past decade was the development of the next generation sequencing. Sequencing of DNA of course. It is relatively easy to sequence DNA – the polymerase is doing it for you – simply add fluorescently labeled nucleotides. For RNA sequencing, we simply convert it into DNA. We now even have a method for in situ sequencing of RNA. But proteins pose a challenge. Now, maybe, this challenge can be overcome with a new-old method to sequence peptides.
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